Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

Chapter 1 Molecular Basis of Thyroid Hormone Action

Chapter 2 Tissues Specific Action of Thyroid Hormones: Insights from Knock out Animal Models

Chapter 3 Learning from Nature’s Experiments on the Thyroid Hormone Receptor; X-Ray Structures of RTH Mutant Ligand-Binding Domains

Chapter 4 Molecular Pathogenesis of Resistance to Thyroid Hormone

Chapter 5 Syndromes of Resistance to Thyroid Hormone: Clinical Aspects

Chapter 6 Resistance to Thyroid Hormone in the Absence of Mutations in the Thyroid Hormone Receptor Genes

Chapter 7 Lessons Learned from TR-β Mutant Mice

Chapter 8 Towards the Rational Design of Hormone Analogs Which Complement Receptor Mutations

Chapter 9 Multi-Factorial Regulation of in Vivo Action of TRβ Mutants. Lessons Learned from RTH Mice with a Targeted Mutation in the TRβ Gene

Chapter 10 The Effect of Vitamin A, Retinoids and Retinoid Receptors on the Hypothalamic-Pituitary-Thyroid Axis

Chapter 11 Pituitary Resistance to Thyroxine Action Due to a Defect in the Type 2 Deiodinase