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Surveillance of hemorrhagic fever and/or neuroinvasive disease: challenges of diagnosis

Overview of attention for article published in Revista de Saúde Pública, June 2021
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Title
Surveillance of hemorrhagic fever and/or neuroinvasive disease: challenges of diagnosis
Published in
Revista de Saúde Pública, June 2021
DOI 10.11606/s1518-8787.2021055003068
Pubmed ID
Authors

Leonardo José Tadeu de Araújo, Lorenzo Lang Gonzalez, Lewis Fletcher Buss, Juliana Mariotti Guerra, David Salas Gomez, Camila Santos da Silva Ferreira, Cinthya Santos Cirqueira, Fábio Ghillardi, Steven S. Witkin, Ester Cerdeira Sabino

Abstract

To evaluate the performance of post mortem laboratory analysis in identifying the causes of hemorrhagic fever and/or neuroinvasive disease in deaths by arbovirus infection. Retrospective cross-sectional study based on the differential analysis and final outcome obtained in patients whose samples underwent laboratory testing for arboviruses at the Pathology Center of the Adolfo Lutz Institute, in São Paulo, Brazil. Of the 1355 adults clinically diagnosed with hemorrhagic fever and/or neuroinvasive disease, the most commonly attributed cause of death and the most common final outcome was dengue fever. Almost half of the samples tested negative on all laboratory tests conducted. The failure to identify the causative agent in a great number of cases highlights a gap in the diagnosis of deaths of unknown etiology. Additional immunohistochemical and molecular assessments need to be added to the post-mortem protocol if all laboratory evaluations performed fail to identify a causative agent. While part of our findings may be due to technical issues related to sample fixation, better information availability when making the initial diagnosis is crucial. Including molecular approaches might lead to a significant advancement in diagnostic accuracy.

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Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Librarian 1 25%
Student > Postgraduate 1 25%
Unknown 2 50%
Readers by discipline Count As %
Medicine and Dentistry 1 25%
Unknown 3 75%