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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0049761 |
| Pubmed ID | |
| Authors |
Melanie Gertz, Giang Thi Tuyet Nguyen, Frank Fischer, Benjamin Suenkel, Christine Schlicker, Benjamin Fränzel, Jana Tomaschewski, Firouzeh Aladini, Christian Becker, Dirk Wolters, Clemens Steegborn |
| Abstract |
Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging processes, and they were suggested to mediate the lifespan extending effect of a low calorie diet. Sirtuin activation by the polyphenol resveratrol can mimic such lifespan extending effects and alleviate metabolic diseases. The mechanism of Sirtuin stimulation is unknown, hindering the development of improved activators. Here we show that resveratrol inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1, against fluorophore-labeled peptide substrates but also against peptides and proteins lacking the non-physiological fluorophore modification. We further present crystal structures of Sirt3 and Sirt5 in complex with fluorogenic substrate peptide and modulator. The compound acts as a top cover, closing the Sirtuin's polypeptide binding pocket and influencing details of peptide binding by directly interacting with this substrate. Our results provide a mechanism for the direct activation of Sirtuins by small molecules and suggest that activators have to be tailored to a specific Sirtuin/substrate pair. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Norway | 1 | 17% |
| Italy | 1 | 17% |
| United Kingdom | 1 | 17% |
| Japan | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 263 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Indonesia | 2 | <1% |
| Portugal | 1 | <1% |
| Turkey | 1 | <1% |
| Canada | 1 | <1% |
| Ukraine | 1 | <1% |
| Unknown | 251 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 21% |
| Student > Master | 37 | 14% |
| Researcher | 32 | 12% |
| Student > Bachelor | 28 | 11% |
| Other | 20 | 8% |
| Other | 41 | 16% |
| Unknown | 49 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 72 | 27% |
| Biochemistry, Genetics and Molecular Biology | 47 | 18% |
| Chemistry | 20 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 7% |
| Medicine and Dentistry | 17 | 6% |
| Other | 28 | 11% |
| Unknown | 60 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2022.
All research outputs
#2,690,125
of 25,909,281 outputs
Outputs from PLOS ONE
#32,613
of 225,993 outputs
Outputs of similar age
#24,254
of 288,168 outputs
Outputs of similar age from PLOS ONE
#589
of 4,697 outputs
Altmetric has tracked 25,909,281 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 225,993 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,168 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 4,697 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.