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Mendeley readers
Attention Score in Context
| Title |
Hydroxyapatite bioactivated bacterial cellulose promotes osteoblast growth and the formation of bone nodules
|
|---|---|
| Published in |
AMB Express, November 2012
|
| DOI | 10.1186/2191-0855-2-61 |
| Pubmed ID | |
| Authors |
Neftaha Tazi, Ze Zhang, Younès Messaddeq, Luciana Almeida-Lopes, Lisinéia M Zanardi, Dennis Levinson, Mahmoud Rouabhia |
| Abstract |
The goal of this study was to investigate the feasibility of bacterial cellulose (BC) scaffold to support osteoblast growth and bone formation. BC was produced by culturing Acetobacter xylinum supplemented with hydroxyapatite (HA) to form BC membranes (without HA) and BC/HA membranes. Membranes were subjected to X-ray photoelectron spectroscopy (XPS) analysis to determine surface element composition. The membranes were further used to evaluate osteoblast growth, alkaline phosphatase activity and bone nodule formation. BC was free of calcium and phosphate. However, XPS analysis revealed the presence of both calcium (10%) and phosphate (10%) at the surface of the BC/HA membrane. Osteoblast culture showed that BC alone was non-toxic and could sustain osteoblast adhesion. Furthermore, osteoblast adhesion and growth were significantly (p ≤0.05) increased on BC/HA membranes as compared to BC alone. Both BC and BC/HA membranes improved osteoconductivity, as confirmed by the level of alkaline phosphatase (ALP) activity that increased from 2.5 mM with BC alone to 5.3 mM with BC/HA. BC/HA membranes also showed greater nodule formation and mineralization than the BC membrane alone. This was confirmed by Alizarin red staining (ARS) and energy dispersive X-ray spectroscopy (EDX). This work demonstrates that both BC and BC/HA may be useful in bone tissue engineering. |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 118 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 21% |
| Researcher | 18 | 15% |
| Student > Master | 16 | 13% |
| Student > Doctoral Student | 10 | 8% |
| Student > Bachelor | 9 | 8% |
| Other | 18 | 15% |
| Unknown | 23 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Materials Science | 19 | 16% |
| Agricultural and Biological Sciences | 13 | 11% |
| Chemistry | 11 | 9% |
| Engineering | 10 | 8% |
| Medicine and Dentistry | 9 | 8% |
| Other | 26 | 22% |
| Unknown | 31 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2023.
All research outputs
#7,446,758
of 23,416,487 outputs
Outputs from AMB Express
#160
of 1,255 outputs
Outputs of similar age
#79,369
of 279,681 outputs
Outputs of similar age from AMB Express
#6
of 18 outputs
Altmetric has tracked 23,416,487 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,255 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,681 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.