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Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, March 2016
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Title
Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Published in
Brazilian Journal of Medical and Biological Research, March 2016
DOI 10.1590/1414-431x20155003
Pubmed ID
Authors

Bocco, B.M., Fernandes, G.W., Lorena, F.B., Cysneiros, R.M., Christoffolete, M.A., Grecco, S.S., Lancellotti, C.L., Romoff, P., Lago, J.H.G., Bianco, A.C., Ribeiro, M.O., Bocco, B.M., Fernandes, G.W., Lorena, F.B., Cysneiros, R.M., Christoffolete, M.A., Grecco, S.S., Lancellotti, C.L., Romoff, P., Lago, J.H.G., Bianco, A.C., Ribeiro, M.O.

Abstract

Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 20%
Student > Ph. D. Student 7 20%
Student > Bachelor 3 9%
Student > Doctoral Student 3 9%
Researcher 2 6%
Other 7 20%
Unknown 6 17%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 5 14%
Biochemistry, Genetics and Molecular Biology 5 14%
Medicine and Dentistry 5 14%
Chemistry 3 9%
Nursing and Health Professions 2 6%
Other 3 9%
Unknown 12 34%