Chapter title |
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
|
---|---|
Chapter number | 5 |
Book title |
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
|
Published in |
Advances in experimental medicine and biology, August 2016
|
DOI | 10.1007/978-3-319-39406-0_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-939404-6, 978-3-31-939406-0
|
Authors |
Dransfield, Ian, Farnworth, Sarah, Ian Dransfield, Sarah Farnworth |
Editors |
Christopher D. Gregory |
Abstract |
The receptor tyrosine kinases Axl and Mer subserve the process of termination of proinflammatory signaling and have key roles in both the resolution of inflammation and restoration of homeostasis. Axl functions prominently under conditions of tissue stress or in response to infection, whereas Mer has a major role in maintenance of homeostasis within tissues. Distinct patterns of expression of Axl and Mer underlie their clearly defined functional roles during the initiation and progression of inflammation. Axl and Mer are expressed by tumor cells and by infiltrating inflammatory cells and the regulation of cellular function via Axl and Mer signaling is also important for tumorigenesis, tumor progression, and metastasis. In this review, we consider the divergent functions of Axl and Mer in the context of inflammatory processes within tumors and the implications for development of therapeutic agents targeting these receptors. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 23% |
Student > Bachelor | 3 | 14% |
Researcher | 3 | 14% |
Student > Doctoral Student | 2 | 9% |
Professor | 1 | 5% |
Other | 2 | 9% |
Unknown | 6 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 36% |
Medicine and Dentistry | 5 | 23% |
Agricultural and Biological Sciences | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Unknown | 6 | 27% |