Chapter title |
Metabolism in Cancer
|
---|---|
Chapter number | 5 |
Book title |
Metabolism in Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, August 2016
|
DOI | 10.1007/978-3-319-42118-6_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-942116-2, 978-3-31-942118-6
|
Authors |
McIntyre, Alan, Harris, Adrian L, Alan McIntyre, Adrian L. Harris, Harris, Adrian L. |
Editors |
Thorsten Cramer, Clemens A. Schmitt |
Abstract |
Frequently observed phenotypes of tumours include high metabolic activity, hypoxia and poor perfusion; these act to produce an acidic microenvironment. Cellular function depends on pH homoeostasis, and thus, tumours become dependent on pH regulatory mechanisms. Many of the proteins involved in pH regulation are highly expressed in tumours, and their expression is often of prognostic significance. The more acidic tumour microenvironment also has important implications with regard to chemotherapeutic and radiotherapeutic interventions. In addition, we review pH-sensing mechanisms, the role of pH regulation in tumour phenotype and the use of pH regulatory mechanisms as therapeutic targets. |
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