Chapter title |
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells.
|
---|---|
Chapter number | 1 |
Book title |
Metabolism in Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, August 2016
|
DOI | 10.1007/978-3-319-42118-6_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-942116-2, 978-3-31-942118-6
|
Authors |
Charlene Brault, Almut Schulze, Brault, Charlene, Schulze, Almut |
Editors |
Thorsten Cramer, Clemens A. Schmitt |
Abstract |
One of the prerequisites for cell growth and proliferation is the synthesis of macromolecules, including proteins, nucleic acids and lipids. Cells have to alter their metabolism to allow the production of metabolic intermediates that are the precursors for biomass production. It is now evident that oncogenic signalling pathways target metabolic processes on several levels and metabolic reprogramming has emerged as a hallmark of cancer. The increased metabolic demand of cancer cells also produces selective dependencies that could be targeted for therapeutic intervention. Understanding the role of glucose and lipid metabolism in supporting cancer cell growth and survival is crucial to identify essential processes that could provide therapeutic windows for cancer therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 18% |
Student > Master | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Other | 1 | 9% |
Student > Postgraduate | 1 | 9% |
Other | 0 | 0% |
Unknown | 4 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Medicine and Dentistry | 2 | 18% |
Agricultural and Biological Sciences | 1 | 9% |
Unknown | 5 | 45% |