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Prescription of off-label and unlicensed drugs for preterm infants in a neonatal intensive care unit

Overview of attention for article published in Revista Brasileira de Terapia Intensiva, January 2021
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Title
Prescription of off-label and unlicensed drugs for preterm infants in a neonatal intensive care unit
Published in
Revista Brasileira de Terapia Intensiva, January 2021
DOI 10.5935/0103-507x.20210034
Pubmed ID
Authors

Verônica Cheles Vieira, Renart Santos Costa, Raquel Cristina Gomes Lima, Daiane Borges Queiroz, Danielle Souto de Medeiros

Abstract

To evaluate the use of off-label and unlicensed medications in preterm infants hospitalized in a neonatal intensive care unit. This nonconcurrent cohort study included preterm infants admitted to 3 neonatal intensive care units in 2016 and 2017 who were followed up during the neonatal period. The type and number of medications used were recorded for the entire period and classified based on the Anatomical Therapeutic Chemical. Descriptive and bivariate data analyses were performed to assess associations between the number of drugs used (total, off-label and unlicensed) and the explanatory variables of interest. Four hundred preterm infants received 16,143 prescriptions for 86 different pharmaceuticals; 51.9% of these medications were classified as off-label and 23.5% as unlicensed. The most prescribed drugs were gentamicin and ampicillin (17.5% and 15.5% among off-label, respectively) and caffeine (75.5% among unlicensed). The results indicated significant associations between the use of off-label drugs and lower gestational age, low birth weight, lower 5-minute Apgar score, advanced resuscitation maneuver in the delivery room and death. The prescription of unlicensed drugs was associated with lower gestational age, low birth weight and 5-minute Apgar score below 7. Neonates admitted to neonatal intensive care units are highly exposed to off-label and unlicensed medications. Further studies are needed to achieve greater safety and quality of drug therapy used in neonatology.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 50%
Unknown 1 50%
Readers by discipline Count As %
Nursing and Health Professions 1 50%
Unknown 1 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2021.
All research outputs
#16,519,785
of 18,672,358 outputs
Outputs from Revista Brasileira de Terapia Intensiva
#226
of 290 outputs
Outputs of similar age
#238,018
of 304,110 outputs
Outputs of similar age from Revista Brasileira de Terapia Intensiva
#1
of 1 outputs
Altmetric has tracked 18,672,358 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 290 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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