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Molecular characterisation of prospectively isolated multipotent mesenchymal progenitors provides new insight to the cellular identity of mesenchymal stem cells in mouse bone marrow

Overview of attention for article published in Molecular & Cellular Biology, January 2012
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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1 tweeter
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1 Facebook page
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1 research highlight platform

Readers on

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42 Mendeley
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Title
Molecular characterisation of prospectively isolated multipotent mesenchymal progenitors provides new insight to the cellular identity of mesenchymal stem cells in mouse bone marrow
Published in
Molecular & Cellular Biology, January 2012
DOI 10.1128/mcb.01287-12
Pubmed ID
Authors

Mikael Sigvardsson, H. Qian, A. Badaloni, F. Chiara, J. Stjernberg, N. Polisetti, K. Nihlberg, G. G. Consalez, M. Sigvardsson

Abstract

Despite great progress in the identification of mesenchymal stem cells (MSCs) from bone marrow (BM), our knowledge of their in vivo cellular identity remains limited. We report here that cells expressing the transcription factor Ebf2 in adult BM display characteristics of MSCs. The Ebf2(+) cells are highly clonal and physiologically quiescent. In vivo lineage-tracing experiments, single cell clone transplantations, and in vitro differentiation assays revealed their self-renewal and multilineage differentiation capacity. Gene expression analysis of the freshly sorted Ebf2(+) cells demonstrated the expression of genes previously reported to be associated with MSCs and the coexpression of multiple lineage-associated genes at the single-cell level. Thus, Ebf2 expression is not restricted to committed osteoblast progenitor cells but rather marks a multipotent mesenchymal progenitor cell population in adult mouse BM. These cells do not appear to completely overlap the previously reported MSC populations. These findings provide new insights into the in vivo cellular identity and molecular properties of BM mesenchymal stem and progenitor cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 5%
Germany 1 2%
Brazil 1 2%
Ireland 1 2%
United States 1 2%
Unknown 36 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 50%
Researcher 9 21%
Student > Master 4 10%
Student > Doctoral Student 3 7%
Professor 2 5%
Other 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 50%
Biochemistry, Genetics and Molecular Biology 8 19%
Medicine and Dentistry 8 19%
Unspecified 2 5%
Chemical Engineering 1 2%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2013.
All research outputs
#3,788,013
of 8,059,414 outputs
Outputs from Molecular & Cellular Biology
#2,598
of 3,878 outputs
Outputs of similar age
#125,956
of 293,081 outputs
Outputs of similar age from Molecular & Cellular Biology
#21
of 87 outputs
Altmetric has tracked 8,059,414 research outputs across all sources so far. This one has received more attention than most of these and is in the 50th percentile.
So far Altmetric has tracked 3,878 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,081 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.