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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Complex Modulation of the Aedes aegypti Transcriptome in Response to Dengue Virus Infection
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0050512 |
| Pubmed ID | |
| Authors |
Mariangela Bonizzoni, W. Augustine Dunn, Corey L. Campbell, Ken E. Olson, Osvaldo Marinotti, Anthony A. James |
| Abstract |
Dengue fever is the most important arboviral disease world-wide, with Aedes aegypti being the major vector. Interactions between the mosquito host and dengue viruses (DENV) are complex and vector competence varies among geographically-distinct Ae. aegypti populations. Additionally, dengue is caused by four antigenically-distinct viral serotypes (DENV1-4), each with multiple genotypes. Each virus genotype interacts differently with vertebrate and invertebrate hosts. Analyses of alterations in mosquito transcriptional profiles during DENV infection are expected to provide the basis for identifying networks of genes involved in responses to viruses and contribute to the molecular-genetic understanding of vector competence. In addition, this knowledge is anticipated to support the development of novel disease-control strategies. RNA-seq technology was used to assess genome-wide changes in transcript abundance at 1, 4 and 14 days following DENV2 infection in carcasses, midguts and salivary glands of the Ae. aegypti Chetumal strain. DENV2 affected the expression of 397 Ae. aegypti genes, most of which were down-regulated by viral infection. Differential accumulation of transcripts was mainly tissue- and time-specific. Comparisons of our data with other published reports reveal conservation of functional classes, but limited concordance of specific mosquito genes responsive to DENV2 infection. These results indicate the necessity of additional studies of mosquito-DENV interactions, specifically those focused on recently-derived mosquito strains with multiple dengue virus serotypes and genotypes. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Germany | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| French Polynesia | 1 | <1% |
| South Africa | 1 | <1% |
| Japan | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 186 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 22% |
| Researcher | 44 | 22% |
| Student > Master | 21 | 11% |
| Student > Postgraduate | 12 | 6% |
| Student > Bachelor | 11 | 6% |
| Other | 31 | 16% |
| Unknown | 34 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 72 | 37% |
| Biochemistry, Genetics and Molecular Biology | 44 | 22% |
| Medicine and Dentistry | 13 | 7% |
| Immunology and Microbiology | 11 | 6% |
| Veterinary Science and Veterinary Medicine | 4 | 2% |
| Other | 13 | 7% |
| Unknown | 40 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2012.
All research outputs
#13,140,433
of 22,687,320 outputs
Outputs from PLOS ONE
#103,589
of 193,653 outputs
Outputs of similar age
#154,076
of 277,168 outputs
Outputs of similar age from PLOS ONE
#2,245
of 4,740 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,653 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,168 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,740 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.