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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Overview of attention for article published in Nature, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#46 of 68,640)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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Readers on

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1523 Mendeley
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6 CiteULike
Title
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Published in
Nature, August 2016
DOI 10.1038/nature19323
Pubmed ID
Authors

Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch, Alfred Sandrock

Abstract

Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we report the generation of aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ. In a transgenic mouse model of AD, aducanumab is shown to enter the brain, bind parenchymal Aβ, and reduce soluble and insoluble Aβ in a dose-dependent manner. In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner. This is accompanied by a slowing of clinical decline measured by Clinical Dementia Rating-Sum of Boxes and Mini Mental State Examination scores. The main safety and tolerability findings are amyloid-related imaging abnormalities. These results justify further development of aducanumab for the treatment of AD. Should the slowing of clinical decline be confirmed in ongoing phase 3 clinical trials, it would provide compelling support for the amyloid hypothesis.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 1,523 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 17 1%
United Kingdom 11 <1%
Spain 7 <1%
Germany 5 <1%
Japan 4 <1%
France 4 <1%
Brazil 4 <1%
Netherlands 3 <1%
Egypt 2 <1%
Other 11 <1%
Unknown 1455 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 311 20%
Researcher 310 20%
Student > Bachelor 256 17%
Student > Master 164 11%
Unspecified 112 7%
Other 370 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 310 20%
Medicine and Dentistry 253 17%
Neuroscience 242 16%
Biochemistry, Genetics and Molecular Biology 220 14%
Unspecified 170 11%
Other 328 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3044. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2019.
All research outputs
#231
of 13,102,962 outputs
Outputs from Nature
#46
of 68,640 outputs
Outputs of similar age
#7
of 261,132 outputs
Outputs of similar age from Nature
#2
of 989 outputs
Altmetric has tracked 13,102,962 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 68,640 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 989 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.