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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Overview of attention for article published in Nature, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#39 of 62,263)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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496 Dimensions

Readers on

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1391 Mendeley
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1 CiteULike
Title
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Published in
Nature, September 2016
DOI 10.1038/nature19323
Pubmed ID
Authors

Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch, Alfred Sandrock

Abstract

Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we report the generation of aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ. In a transgenic mouse model of AD, aducanumab is shown to enter the brain, bind parenchymal Aβ, and reduce soluble and insoluble Aβ in a dose-dependent manner. In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner. This is accompanied by a slowing of clinical decline measured by Clinical Dementia Rating-Sum of Boxes and Mini Mental State Examination scores. The main safety and tolerability findings are amyloid-related imaging abnormalities. These results justify further development of aducanumab for the treatment of AD. Should the slowing of clinical decline be confirmed in ongoing phase 3 clinical trials, it would provide compelling support for the amyloid hypothesis.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 1,391 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 17 1%
United Kingdom 11 <1%
Spain 7 <1%
Germany 5 <1%
Brazil 4 <1%
France 4 <1%
Japan 4 <1%
Netherlands 3 <1%
Egypt 2 <1%
Other 12 <1%
Unknown 1322 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 295 21%
Researcher 289 21%
Student > Bachelor 226 16%
Student > Master 151 11%
Student > Doctoral Student 88 6%
Other 342 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 297 21%
Medicine and Dentistry 237 17%
Neuroscience 212 15%
Biochemistry, Genetics and Molecular Biology 199 14%
Unspecified 136 10%
Other 310 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2996. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2018.
All research outputs
#195
of 12,286,894 outputs
Outputs from Nature
#39
of 62,263 outputs
Outputs of similar age
#7
of 262,954 outputs
Outputs of similar age from Nature
#2
of 992 outputs
Altmetric has tracked 12,286,894 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 62,263 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 73.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 992 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.