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Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1

Overview of attention for article published in Journal of Neuroinflammation, January 2016
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Title
Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1
Published in
Journal of Neuroinflammation, January 2016
DOI 10.1186/s12974-016-0677-5
Pubmed ID
Authors

Cabrera, Jorge Rubén, Viejo-Borbolla, Abel, Alcamí, Antonio, Wandosell, Francisco

Abstract

Genital herpes is a painful disease frequently caused by the neurotropic pathogen herpes simplex virus type 2 (HSV-2). We have recently shown that HSV-2-secreted glycoprotein G (SgG2) interacts with and modulates the activity of the neurotrophin nerve growth factor (NGF). This interaction modifies the response of the NGF receptor TrkA, increasing NGF-dependent axonal growth. NGF is not only an axonal growth modulator but also an important mediator of pain and inflammation regulating the amount, localization, and activation of the thermal pain receptor transient receptor potential vanilloid 1 (TRPV1). In this work, we addressed whether SgG2 could contribute to HSV-2-induced pain. Injection of SgG2 in the mouse hindpaw produced a rapid and transient increase in thermal pain sensitivity. At the molecular level, this acute increase in thermal pain induced by SgG2 injection was dependent on differential NGF-induced phosphorylation and in changes in the amount of TrkA and TRPV1 in the dermis. These results suggest that SgG2 alters thermal pain sensitivity by modulating TRPV1 receptor.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 33%
Researcher 3 20%
Student > Ph. D. Student 3 20%
Professor > Associate Professor 1 7%
Student > Doctoral Student 1 7%
Other 2 13%
Readers by discipline Count As %
Medicine and Dentistry 4 27%
Immunology and Microbiology 3 20%
Agricultural and Biological Sciences 3 20%
Biochemistry, Genetics and Molecular Biology 3 20%
Psychology 1 7%
Other 0 0%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2016.
All research outputs
#7,188,814
of 8,314,034 outputs
Outputs from Journal of Neuroinflammation
#907
of 1,049 outputs
Outputs of similar age
#211,359
of 251,801 outputs
Outputs of similar age from Journal of Neuroinflammation
#46
of 56 outputs
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