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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Drug-Eluting Fibers for HIV-1 Inhibition and Contraception
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0049792 |
| Pubmed ID | |
| Authors |
Cameron Ball, Emily Krogstad, Thanyanan Chaowanachan, Kim A. Woodrow |
| Abstract |
Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection in vitro and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 32% |
| United Kingdom | 2 | 11% |
| Nigeria | 1 | 5% |
| Unknown | 10 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 63% |
| Scientists | 4 | 21% |
| Practitioners (doctors, other healthcare professionals) | 3 | 16% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 2% |
| Portugal | 1 | <1% |
| Ireland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 118 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 26% |
| Student > Master | 17 | 14% |
| Student > Bachelor | 10 | 8% |
| Researcher | 9 | 7% |
| Student > Postgraduate | 8 | 7% |
| Other | 13 | 11% |
| Unknown | 34 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 11% |
| Materials Science | 12 | 10% |
| Medicine and Dentistry | 12 | 10% |
| Engineering | 11 | 9% |
| Chemistry | 10 | 8% |
| Other | 29 | 24% |
| Unknown | 36 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 164. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2016.
All research outputs
#212,420
of 23,189,371 outputs
Outputs from PLOS ONE
#3,172
of 198,029 outputs
Outputs of similar age
#1,407
of 279,664 outputs
Outputs of similar age from PLOS ONE
#54
of 4,741 outputs
Altmetric has tracked 23,189,371 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 198,029 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,664 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 4,741 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.