Title |
Hematopoietic Stem Cell Therapy for Multiple Sclerosis: Top 10 Lessons Learned
|
---|---|
Published in |
Neurotherapeutics, January 2013
|
DOI | 10.1007/s13311-012-0162-5 |
Pubmed ID | |
Authors |
Harold L. Atkins, Mark S. Freedman |
Abstract |
Reports from more than 600 hematopoietic stem cell transplants (HSCT) have appeared in the medical literature for the last 1 and one-half decades. The patient's own stem cells are harvested and stored temporarily while high doses of chemotherapy and biologics are used to destroy the auto-destructive immune system. The immune system is regenerated from the infused autologous hematopoietic stem cells. Increasing clinical experience has refined patient selection criteria and management in the peri-transplant period leading to a reduction in treatment-related complications. HSCT, when used to treat patients with aggressive highly active multiple sclerosis, can reduce or eliminate ongoing clinical relapses, halt further progression, and reduce the burden of disability in some patients, in the absence of chronic treatment with disease-modifying agents. The top 10 lessons learned from the growing experience using HSCT for the treatment of multiple sclerosis are discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 25% |
United States | 1 | 13% |
Australia | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 88% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 1% |
Brazil | 2 | 1% |
Chile | 1 | <1% |
Germany | 1 | <1% |
Korea, Republic of | 1 | <1% |
Unknown | 136 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 15% |
Student > Bachelor | 22 | 15% |
Researcher | 15 | 10% |
Student > Master | 14 | 10% |
Other | 12 | 8% |
Other | 24 | 17% |
Unknown | 34 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 42 | 29% |
Agricultural and Biological Sciences | 20 | 14% |
Neuroscience | 14 | 10% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Immunology and Microbiology | 3 | 2% |
Other | 16 | 11% |
Unknown | 42 | 29% |