Title |
Malaria in infants aged less than six months - is it an area of unmet medical need?
|
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Published in |
Malaria Journal, December 2012
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DOI | 10.1186/1475-2875-11-400 |
Pubmed ID | |
Authors |
Umberto D’Alessandro, David Ubben, Kamal Hamed, Serign Jawo Ceesay, Joseph Okebe, Makie Taal, Eugene Kaman Lama, Moussa Keita, Lamine Koivogui, Alain Nahum, Kalifa Bojang, Aja Adam Jagne Sonko, Honorat Francis Lalya, Bernard Brabin |
Abstract |
Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an overlap of clinical manifestations. In addition, there is little information on the use of artemisinin-based combination therapy in young infants. There is the need for a more accurate estimate of the parasite prevalence and the incidence of clinical malaria in infants under 6 months old, as well as a better characterization of risk factors, pharmacokinetic profiles, safety and efficacy of currently available anti-malarial treatments, in order to develop evidence-based treatment guidelines for this population. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Uganda | 3 | 43% |
South Africa | 1 | 14% |
Netherlands | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 158 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 16% |
Researcher | 23 | 14% |
Student > Postgraduate | 23 | 14% |
Student > Ph. D. Student | 20 | 12% |
Student > Doctoral Student | 10 | 6% |
Other | 26 | 16% |
Unknown | 34 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 59 | 36% |
Agricultural and Biological Sciences | 22 | 14% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Nursing and Health Professions | 6 | 4% |
Immunology and Microbiology | 6 | 4% |
Other | 19 | 12% |
Unknown | 43 | 27% |