17/ORF3a-Mediated Incomplete Autophagy Facilitates SARS-CoV-2 Replication, 2021-07-27 “..SARS-CoV-2 ORF3a interacts with autophagy regulator UVRAG to facilitate PI3KC3-C1 (Beclin-1- Vps34-Atg14) but selectively inhibit PI3KC3-C2 (Beclin-1-Vps34-UVRAG).”
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την κλινική σημασία. Υποθετικά, η αρθρογραφία δίνει κάποια hints: ORF3a is a viroporin, an integral membrane protein able to function as an ion channel that may promote virus release. https://t.co/OuzQYwaIDX https://t.co/DgKS2HGHuY
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The mechanism of ORF3a's induction of incomplete autophagy: >> ORF3a-UVRAG interaction renders UVRAG less competitive than Atg14 for Beclin 1 binding ... resulting in more efficient autophagosome formation but inhibition of autophagosome maturation.
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New article: ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication https://t.co/QZKoWWrXho #coronavirus #COVID19 #2019ncov https://t.co/HNjFKn3obA