Title |
Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury
|
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Published in |
Journal of Neuroinflammation, October 2012
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DOI | 10.1186/1742-2094-9-247 |
Pubmed ID | |
Authors |
Jenna M Ziebell, Samuel E Taylor, Tuoxin Cao, Jordan L Harrison, Jonathan Lifshitz |
Abstract |
Since their discovery, the morphology of microglia has been interpreted to mirror their function, with ramified microglia constantly surveying the micro-environment and rapidly activating when changes occur. In 1899, Franz Nissl discovered what we now recognize as a distinct microglial activation state, microglial rod cells (Stäbchenzellen), which he observed adjacent to neurons. These rod-shaped microglia are typically found in human autopsy cases of paralysis of the insane, a disease of the pre-penicillin era, and best known today from HIV-1-infected brains. Microglial rod cells have been implicated in cortical 'synaptic stripping' but their exact role has remained unclear. This is due at least in part to a scarcity of experimental models. Now we have noted these rod microglia after experimental diffuse brain injury in brain regions that have an associated sensory sensitivity. Here, we describe the time course, location, and surrounding architecture associated with rod microglia following experimental diffuse traumatic brain injury (TBI). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | <1% |
Unknown | 133 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 26 | 19% |
Student > Ph. D. Student | 25 | 19% |
Student > Doctoral Student | 17 | 13% |
Student > Master | 13 | 10% |
Student > Bachelor | 12 | 9% |
Other | 17 | 13% |
Unknown | 24 | 18% |
Readers by discipline | Count | As % |
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Neuroscience | 33 | 25% |
Agricultural and Biological Sciences | 27 | 20% |
Medicine and Dentistry | 13 | 10% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Engineering | 7 | 5% |
Other | 14 | 10% |
Unknown | 32 | 24% |