Title |
Muscle reorganisation through local injection of stem cells in the diaphragm of mdx mice
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Published in |
Acta Veterinaria Scandinavica, December 2012
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DOI | 10.1186/1751-0147-54-73 |
Pubmed ID | |
Authors |
Thais Borges Lessa, Rafael Cardoso Carvalho, André Luis Rezende Franciolli, Lilian Jesus de Oliveira, RodrigoSilvadaNunes Barreto, David Feder, Fabiana Fernandes Bressan, Maria Angélica Miglino, Carlos Eduardo Ambrósio |
Abstract |
The diaphragm is the major respiratory muscle affected by Duchenne muscular dystrophy (DMD) and is responsible for causing 80% of deaths. The use of mechanical forces that act on the body or intermittent pressure on the airways improves the quality of life of patients but does not prevent the progression of respiratory failure. Thus, diseases that require tissue repair, such as DMD, represent a group of pathologies that have great potential for cell therapy. The application of stem cells directly into the diaphragm instead of systemic application can reduce cell migration to other affected areas and increase the chances of muscle reorganisation. The mdx mouse is a suitable animal model for this research because its diaphragmatic phenotype is similar to human DMD. Therefore, the aim of this study was to assess the potential cell implantation in the diaphragm muscle after the xenotransplantation of stem cells. |
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