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Mesenchymal stem cells for cartilage repair in osteoarthritis

Overview of attention for article published in Stem Cell Research & Therapy, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
facebook
1 Facebook page

Citations

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146 Dimensions

Readers on

mendeley
208 Mendeley
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Title
Mesenchymal stem cells for cartilage repair in osteoarthritis
Published in
Stem Cell Research & Therapy, January 2012
DOI 10.1186/scrt116
Pubmed ID
Authors

Pawan K Gupta, Anjan K Das, Anoop Chullikana, Anish S Majumdar

Abstract

ABSTRACT: Osteoarthritis (OA) is a degenerative disease of the connective tissue and progresses with age in the older population or develops in young athletes following sports-related injury. The articular cartilage is especially vulnerable to damage and has poor potential for regeneration because of the absence of vasculature within the tissue. Normal load-bearing capacity and biomechanical properties of thinning cartilage are severely compromised during the course of disease progression. Although surgical and pharmaceutical interventions are currently available for treating OA, restoration of normal cartilage function has been difficult to achieve. Since the tissue is composed primarily of chondrocytes distributed in a specialized extracellular matrix bed, bone marrow stromal cells (BMSCs), also known as bone marrow-derived 'mesenchymal stem cells' or 'mesenchymal stromal cells', with inherent chondrogenic differentiation potential appear to be ideally suited for therapeutic use in cartilage regeneration. BMSCs can be easily isolated and massively expanded in culture in an undifferentiated state for therapeutic use. Owing to their potential to modulate local microenvironment via anti-inflammatory and immunosuppressive functions, BMSCs have an additional advantage for allogeneic application. Moreover, by secreting various bioactive soluble factors, BMSCs can protect the cartilage from further tissue destruction and facilitate regeneration of the remaining progenitor cells in situ. This review broadly describes the advances made during the last several years in BMSCs and their therapeutic potential for repairing cartilage damage in OA.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 2 <1%
Korea, Republic of 2 <1%
Mexico 2 <1%
Hong Kong 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 199 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 23%
Researcher 32 15%
Student > Master 30 14%
Student > Bachelor 22 11%
Other 18 9%
Other 39 19%
Unknown 19 9%
Readers by discipline Count As %
Medicine and Dentistry 64 31%
Agricultural and Biological Sciences 44 21%
Biochemistry, Genetics and Molecular Biology 32 15%
Engineering 11 5%
Materials Science 6 3%
Other 22 11%
Unknown 29 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2018.
All research outputs
#1,564,566
of 14,056,657 outputs
Outputs from Stem Cell Research & Therapy
#116
of 1,274 outputs
Outputs of similar age
#27,532
of 249,662 outputs
Outputs of similar age from Stem Cell Research & Therapy
#4
of 22 outputs
Altmetric has tracked 14,056,657 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.