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New approaches in antimalarial drug discovery and development: a review

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, November 2012
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Title
New approaches in antimalarial drug discovery and development: a review
Published in
Memórias do Instituto Oswaldo Cruz, November 2012
DOI 10.1590/s0074-02762012000700001
Pubmed ID
Authors

Anna Caroline C Aguiar, Eliana MM da Rocha, Nicolli B de Souza, Tanos CC França, Antoniana U Krettli

Abstract

Malaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem has since been aggravated by a decreased sensitivity of Plasmodium vivax to chloroquine. This review discusses strategies for evaluating the antimalarial activity of new compounds in vitro and in animal models ranging from conventional tests to the latest high-throughput screening technologies. Antimalarial discovery approaches include the following: the discovery of antimalarials from natural sources, chemical modifications of existing antimalarials, the development of hybrid compounds, testing of commercially available drugs that have been approved for human use for other diseases and molecular modelling using virtual screening technology and docking. Using these approaches, thousands of new drugs with known molecular specificity and active against P. falciparum have been selected. The inhibition of haemozoin formation in vitro, an indirect test that does not require P. falciparum cultures, has been described and this test is believed to improve antimalarial drug discovery. Clinical trials conducted with new funds from international agencies and the participation of several industries committed to the eradication of malaria should accelerate the discovery of drugs that are as effective as artemisinin derivatives, thus providing new hope for the control of malaria.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 1%
Indonesia 1 <1%
Switzerland 1 <1%
Ghana 1 <1%
United Kingdom 1 <1%
Unknown 218 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 20%
Student > Master 40 18%
Student > Bachelor 27 12%
Researcher 24 11%
Student > Postgraduate 15 7%
Other 39 17%
Unknown 34 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 19%
Chemistry 41 18%
Medicine and Dentistry 28 12%
Biochemistry, Genetics and Molecular Biology 23 10%
Pharmacology, Toxicology and Pharmaceutical Science 21 9%
Other 17 8%
Unknown 52 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2012.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#1,299
of 1,502 outputs
Outputs of similar age
#175,864
of 196,737 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#9
of 10 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,737 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.