Title |
Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
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Published in |
Genetics and Molecular Biology, October 2012
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DOI | 10.1590/s1415-47572012005000056 |
Pubmed ID | |
Authors |
Luize Otero, Daiane Correa de Souza, Rita de Cássia Tavares, Bernadete Evangelho Gomes, Telma França Padilha, Luiz Fernando Bouzas, Teresa de Souza Fernandez, Eliana Abdelhay |
Abstract |
Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells. |
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