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Design of compound libraries for fragment screening

Overview of attention for article published in Perspectives in Drug Discovery and Design, March 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#25 of 949)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
3 blogs
twitter
2 X users

Citations

dimensions_citation
69 Dimensions

Readers on

mendeley
132 Mendeley
citeulike
4 CiteULike
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Title
Design of compound libraries for fragment screening
Published in
Perspectives in Drug Discovery and Design, March 2009
DOI 10.1007/s10822-009-9264-5
Pubmed ID
Authors

Niklas Blomberg, David A. Cosgrove, Peter W. Kenny, Karin Kolmodin

Abstract

Approaches to the design of libraries for fragment screening are illustrated with reference to a 20 k generic fragment screening library and a 1.2 k generic NMR screening library. Tools and methods for library design that have been developed within AstraZeneca are described, including Foyfi fingerprints and the Flush program for neighborhood characterization. It will be shown how Flush and the BigPicker, which selects maximally diverse sets of compounds, are used to apply the Core and Layer method for library design. Approaches to partitioning libraries into cocktails are also described.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 4%
United States 4 3%
Germany 2 2%
Denmark 2 2%
Sweden 1 <1%
India 1 <1%
Chile 1 <1%
Portugal 1 <1%
Spain 1 <1%
Other 1 <1%
Unknown 113 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 50 38%
Student > Ph. D. Student 23 17%
Other 14 11%
Student > Master 9 7%
Professor 8 6%
Other 16 12%
Unknown 12 9%
Readers by discipline Count As %
Chemistry 51 39%
Agricultural and Biological Sciences 29 22%
Biochemistry, Genetics and Molecular Biology 11 8%
Computer Science 10 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 10 8%
Unknown 16 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2023.
All research outputs
#1,726,106
of 25,457,297 outputs
Outputs from Perspectives in Drug Discovery and Design
#25
of 949 outputs
Outputs of similar age
#4,935
of 109,848 outputs
Outputs of similar age from Perspectives in Drug Discovery and Design
#1
of 7 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 949 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,848 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them