Title |
Two randomized controlled clinical trials to study the effectiveness of prednisolone treatment in preventing and restoring clinical nerve function loss in leprosy: the TENLEP study protocols
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Published in |
BMC Neurology, December 2012
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DOI | 10.1186/1471-2377-12-159 |
Pubmed ID | |
Authors |
Inge Wagenaar, Wim Brandsma, Erik Post, Wim van Brakel, Diana Lockwood, Peter Nicholls, Paul Saunderson, Cairns Smith, Einar Wilder-Smith, Jan Hendrik Richardus |
Abstract |
Nerve damage in leprosy often causes disabilities and deformities. Prednisolone is used to treat nerve function impairment (NFI). However, optimal dose and duration of prednisolone treatment has not been established yet. Besides treating existing NFI it would be desirable to prevent NFI. Studies show that before NFI is clinically detectable, nerves often show subclinical damage. Within the 'Treatment of Early Neuropathy in LEProsy' (TENLEP) study two double blind randomized controlled trials (RCT) will be carried out: a trial to establish whether prednisolone treatment of 32 weeks duration is more effective than 20 weeks in restoring nerve function in leprosy patients with clinical NFI (Clinical trial) and a trial to determine whether prednisolone treatment of early sub-clinical NFI can prevent clinical NFI (Subclinical trial). |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Netherlands | 1 | 33% |
Egypt | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 71 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 18% |
Researcher | 10 | 14% |
Student > Doctoral Student | 7 | 10% |
Student > Bachelor | 7 | 10% |
Student > Ph. D. Student | 4 | 6% |
Other | 13 | 18% |
Unknown | 17 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 34% |
Nursing and Health Professions | 9 | 13% |
Psychology | 3 | 4% |
Arts and Humanities | 3 | 4% |
Social Sciences | 2 | 3% |
Other | 11 | 15% |
Unknown | 19 | 27% |