Title |
PECAM1+/Sca1+/CD38+ Vascular Cells Transform into Myofibroblast-Like Cells in Skin Wound Repair
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Published in |
PLOS ONE, January 2013
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DOI | 10.1371/journal.pone.0053262 |
Pubmed ID | |
Authors |
Julia Etich, Vera Bergmeier, Christian Frie, Sandra Kreft, Lena Bengestrate, Sabine Eming, Cornelia Mauch, Beate Eckes, Hikmet Ulus, Frances E. Lund, Gunter Rappl, Hinrich Abken, Mats Paulsson, Bent Brachvogel |
Abstract |
Skin injury induces the formation of new blood vessels by activating the vasculature in order to restore tissue homeostasis. Vascular cells may also differentiate into matrix-secreting contractile myofibroblasts to promote wound closure. Here, we characterize a PECAM1(+)/Sca1(+) vascular cell population in mouse skin, which is highly enriched in wounds at the peak of neoangiogenesis and myofibroblast formation. These cells express endothelial and perivascular markers and present the receptor CD38 on their surface. PECAM1(+)/Sca1(+)/CD38(+) cells proliferate upon wounding and could give rise to α-SMA(+) myofibroblast-like cells. CD38 stimulation in immunodeficient mice reduced the wound size at the peak of neoangiogenesis and myofibroblast formation. In humans a corresponding cell population was identified, which was enriched in sprouting vessels of basal cell carcinoma biopsies. The results indicate that PECAM1(+)/Sca1(+)/CD38(+) vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. Moreover, CD38 signaling modulates PECAM1(+)/Sca1(+)/CD38(+) cell activation in the healing process implying CD38 as a target for anti-angiogenic therapies in human basal cell carcinoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 28% |
Student > Master | 5 | 14% |
Researcher | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Student > Postgraduate | 3 | 8% |
Other | 6 | 17% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 31% |
Biochemistry, Genetics and Molecular Biology | 6 | 17% |
Medicine and Dentistry | 5 | 14% |
Immunology and Microbiology | 4 | 11% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 8% |
Unknown | 6 | 17% |