https://t.co/lAR6uRHMHd "Our findings uncovered a previously unknown mechanism underlying the control of cellular dopamine expression, with normal levels of dopamine synthesis being maintained through a balance between Fe2+ and Zn2+ ions."
https://t.co/lAR6uRHMHd "Zinc ion (Zn2+) negatively regulates dopamine synthesis through direct inhibition of TH activity, by antagonizing Fe2+ binding to TH, thus rendering the enzyme ineffective or non-functional."
https://t.co/lAR6uRHMHd "Due to its critical functions, DA expression levels in the brain are tightly controlled, with one important & rate-limiting step in its biosynthetic pathway being catalyzed by tyrosine hydroxylase (TH), an enzyme that uses iro
Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster #MECFS #LongCovid https://t.co/lAR6uRHMHd