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Oxidants, antioxidants and the current incurability of metastatic cancers

Overview of attention for article published in Open Biology, January 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 1,049)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
14 news outlets
blogs
14 blogs
twitter
370 tweeters
weibo
39 weibo users
facebook
73 Facebook pages
googleplus
15 Google+ users
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
283 Dimensions

Readers on

mendeley
523 Mendeley
citeulike
5 CiteULike
Title
Oxidants, antioxidants and the current incurability of metastatic cancers
Published in
Open Biology, January 2013
DOI 10.1098/rsob.120144
Pubmed ID
Authors

Jim Watson

Abstract

The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle. As mesenchymal cancers evolve from their epithelial cell progenitors, they almost inevitably possess much-heightened amounts of antioxidants that effectively block otherwise highly effective oxidant therapies. Also key to better understanding is why and how the anti-diabetic drug metformin (the world's most prescribed pharmaceutical product) preferentially kills oxidant-deficient mesenchymal p53(- -) cells. A much faster timetable should be adopted towards developing more new drugs effective against p53(- -) cancers.

Twitter Demographics

The data shown below were collected from the profiles of 370 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 523 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 2%
United Kingdom 10 2%
Spain 5 <1%
Australia 4 <1%
Germany 3 <1%
Brazil 3 <1%
Nigeria 2 <1%
Canada 2 <1%
Israel 1 <1%
Other 11 2%
Unknown 470 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 120 23%
Student > Ph. D. Student 99 19%
Student > Master 53 10%
Other 40 8%
Professor 39 7%
Other 133 25%
Unknown 39 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 182 35%
Medicine and Dentistry 84 16%
Biochemistry, Genetics and Molecular Biology 69 13%
Chemistry 46 9%
Engineering 15 3%
Other 69 13%
Unknown 58 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 545. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2022.
All research outputs
#35,199
of 22,554,315 outputs
Outputs from Open Biology
#2
of 1,049 outputs
Outputs of similar age
#208
of 297,689 outputs
Outputs of similar age from Open Biology
#2
of 14 outputs
Altmetric has tracked 22,554,315 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,049 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,689 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.