Title |
BM-Map: an efficient software package for accurately allocating multireads of RNA-sequencing data
|
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Published in |
BMC Genomics, December 2012
|
DOI | 10.1186/1471-2164-13-s8-s9 |
Pubmed ID | |
Authors |
Yuan, Clift Norris, Yanxun Xu, Kam-Wah Tsui, Yuan Ji, Han Liang |
Abstract |
RNA sequencing (RNA-seq) has become a major tool for biomedical research. A key step in analyzing RNA-seq data is to infer the origin of short reads in the source genome, and for this purpose, many read alignment/mapping software programs have been developed. Usually, the majority of mappable reads can be mapped to one unambiguous genomic location, and these reads are called unique reads. However, a considerable proportion of mappable reads can be aligned to more than one genomic location with the same or similar fidelities, and they are called "multireads". Allocating these multireads is challenging but critical for interpreting RNA-seq data. We recently developed a Bayesian stochastic model that allocates multireads more accurately than alternative methods (Ji et al. Biometrics 2011). |
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