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Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital

Overview of attention for article published in Clinics, November 2021
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#25 of 1,257)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
8 news outlets
twitter
24 X users

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
122 Mendeley
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Title
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
Published in
Clinics, November 2021
DOI 10.6061/clinics/2021/e3511
Pubmed ID
Authors

Thais T. Fink, Heloisa H.S. Marques, Bruno Gualano, Livia Lindoso, Vera Bain, Camilla Astley, Fernanda Martins, Denise Matheus, Olivia M. Matsuo, Priscila Suguita, Vitor Trindade, Camila S.Y. Paula, Sylvia C.L. Farhat, Patricia Palmeira, Gabriela N. Leal, Lisa Suzuki, Vicente Odone, Magda Carneiro-Sampaio, Alberto José S. Duarte, Leila Antonangelo, Linamara R. Batisttella, Guilherme V. Polanczyk, Rosa Maria R. Pereira, Carlos Roberto R. Carvalho, Carlos A. Buchpiguel, Ana Claudia L. Xavier, Marilia Seelaender, Clovis Artur Silva, Maria Fernanda B. Pereira, HC-FMUSP Pediatric Post-COVID-19 Study Group, Adriana M.E. Sallum, Alexandra V.M. Brentani, Álvaro José S. Neto, Amanda Ihara, Andrea R. Santos, Ana Pinheiro M. Canton, Andreia Watanabe, Angélica C. dos Santos, Antonio C. Pastorino, Bernadette D.G.M. Franco, Bruna Caruzo, Carina Ceneviva, Carolina C.M.F. Martins, Danilo Prado, Deipara M. Abellan, Fabiana B. Benatti, Fabiana Smaria, Fernanda T. Gonçalves, Fernando D. Penteado, Gabriela S. F. de Castro, Guilherme S. Gonçalves, Hamilton Roschel, Ilana R. Disi, Isabela G. Marques, Inar A. Castro, Izabel M. Buscatti, Jaline Z. Faiad, Jarlei Fiamoncini, Joaquim C. Rodrigues, Jorge D.A. Carneiro, Jose A. Paz, Juliana C. Ferreira, Juliana C.O. Ferreira, Katia R. Silva, Karina L.M. Bastos, Katia Kozu, Lilian M. Cristofani, Lucas V.B. Souza, Lucia M.A. Campos, Luiz Vicente R.F. Silva, Marcelo T. Sapienza, Marcos S. Lima, Marlene P. Garanito, Márcia F.A. Santos, Mayra B. Dorna, Nadia E. Aikawa, Nadia Litvinov, Neusa K. Sakita, Paula V.V. Gaiolla, Paula Pasqualucci, Ricardo K. Toma, Simone Correa-Silva, Sofia M. Sieczkowska, Marta Imamura, Silvana Forsait, Vera A. Santos, Yingying Zheng

Abstract

To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19). This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 122 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 9%
Student > Master 7 6%
Student > Postgraduate 7 6%
Researcher 5 4%
Student > Ph. D. Student 5 4%
Other 11 9%
Unknown 76 62%
Readers by discipline Count As %
Medicine and Dentistry 21 17%
Nursing and Health Professions 8 7%
Psychology 3 2%
Unspecified 2 2%
Sports and Recreations 2 2%
Other 6 5%
Unknown 80 66%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#661,665
of 26,745,229 outputs
Outputs from Clinics
#25
of 1,257 outputs
Outputs of similar age
#16,103
of 531,731 outputs
Outputs of similar age from Clinics
#1
of 21 outputs
Altmetric has tracked 26,745,229 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,257 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 531,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.