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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231
|
|---|---|
| Published in |
BMC Pharmacology and Toxicology, January 2013
|
| DOI | 10.1186/2050-6511-14-6 |
| Pubmed ID | |
| Authors |
Mariel Núñez, Vanina Medina, Graciela Cricco, Máximo Croci, Claudia Cocca, Elena Rivera, Rosa Bergoc, Gabriela Martín |
| Abstract |
Glibenclamide (Gli) binds to the sulphonylurea receptor (SUR) that is a regulatory subunit of ATP-sensitive potassium channels (KATP channels). Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. This drug is widely used for treatment of type 2-diabetes and it has been signaled as antiproliferative in several tumor cell lines. In previous experiments we demonstrated the antitumoral effect of Gli in mammary tumors induced in rats. The aim of the present work was to investigate the effect of Gli on MDA-MB-231 breast cancer cell proliferation and to examine the possible pathways involved in this action. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 62 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 23% |
| Researcher | 10 | 16% |
| Student > Master | 9 | 14% |
| Student > Doctoral Student | 7 | 11% |
| Student > Bachelor | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 25% |
| Biochemistry, Genetics and Molecular Biology | 13 | 20% |
| Medicine and Dentistry | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Immunology and Microbiology | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 15 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2013.
All research outputs
#14,616,041
of 22,693,205 outputs
Outputs from BMC Pharmacology and Toxicology
#219
of 438 outputs
Outputs of similar age
#174,420
of 282,285 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#7
of 14 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 438 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,285 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.