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Characterization of a Stable, Metronidazole-Resistant Clostridium difficile Clinical Isolate

Overview of attention for article published in PLOS ONE, January 2013
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  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Title
Characterization of a Stable, Metronidazole-Resistant Clostridium difficile Clinical Isolate
Published in
PLOS ONE, January 2013
DOI 10.1371/journal.pone.0053757
Pubmed ID
Authors

Tarah Lynch, Patrick Chong, Jason Zhang, Romeo Hizon, Tim Du, Morag R. Graham, Daniel R. Beniac, Timothy F. Booth, Pamela Kibsey, Mark Miller, Denise Gravel, Michael R. Mulvey, Canadian Nosocomial Infection Surveillance Program

Abstract

Clostridium difficile are gram-positive, spore forming anaerobic bacteria that are the leading cause of healthcare-associated diarrhea, usually associated with antibiotic usage. Metronidazole is currently the first-line treatment for mild to moderate C. difficile diarrhea however recurrence occurs at rates of 15-35%. There are few reports of C. difficile metronidazole resistance in the literature, and when observed, the phenotype has been transient and lost after storage or exposure of the bacteria to freeze/thaw cycles. Owing to the unstable nature of the resistance phenotype in the laboratory, clinical significance and understanding of the resistance mechanisms is lacking.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 87 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 14%
Student > Master 11 13%
Researcher 10 11%
Student > Bachelor 10 11%
Other 9 10%
Other 22 25%
Unknown 13 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 22%
Immunology and Microbiology 15 17%
Medicine and Dentistry 12 14%
Biochemistry, Genetics and Molecular Biology 12 14%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 10 11%
Unknown 16 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2020.
All research outputs
#12,675,514
of 22,693,205 outputs
Outputs from PLOS ONE
#98,070
of 193,724 outputs
Outputs of similar age
#152,303
of 284,627 outputs
Outputs of similar age from PLOS ONE
#2,253
of 4,841 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,724 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,627 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,841 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.