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Serological profiles in nursery piglets colonized with Staphylococcus aureus

Overview of attention for article published in Veterinary Research, January 2013
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Title
Serological profiles in nursery piglets colonized with Staphylococcus aureus
Published in
Veterinary Research, January 2013
DOI 10.1186/1297-9716-44-4
Pubmed ID
Authors

Crombé F, Vanderhaeghen W, de Vogel CP, Van Wamel WJ, Barbe K, Hermans K, Haesebrouck F, Butaye P, Crombé, Florence, Vanderhaeghen, Wannes, de Vogel, Corné P, Van Wamel, Willem J, Barbe, Kurt, Hermans, Katleen, Haesebrouck, Freddy, Butaye, Patrick

Abstract

At present, the immune response of pigs in relation to Staphylococcus aureus carriage is poorly understood. This study was aimed at investigating the dynamics of the anti-staphylococcal humoral immune response in methicillin-susceptible S. aureus (MSSA)-positive piglets and at assessing the effect of the experimental introduction of a methicillin-resistant S. aureus (MRSA) Sequence Type (ST) 398 strain. Therefore, serum samples were collected at different times from 31 weaned piglets originating from four different sows. Twenty-four out of the 31 piglets were challenged with MRSA ST398. The serum samples were analyzed for IgG antibodies to 39 S. aureus antigens, using a multiplex bead-based assay (xMAP technology, Luminex Corporation). Though antibody responses showed broad inter-individual variability, serological results appeared to be clustered by litter of origin. For most antigens, an age-related response was observed with an apparent increase in antibody titers directed against staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM), which have been shown to play a role in S. aureus colonization. In most animals, antibody titers directed against staphylococcal toxins or immune-modulating proteins decreased with age, possibly reflecting the absence of bacterial invasion. The introduction of MRSA ST398 did not elicit a significant humoral immune reaction.This study describes, for the first time, the humoral immune response in weaned pigs colonized with S. aureus.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Nigeria 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 20%
Researcher 4 16%
Professor 4 16%
Student > Bachelor 3 12%
Student > Master 3 12%
Other 4 16%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 28%
Veterinary Science and Veterinary Medicine 4 16%
Medicine and Dentistry 4 16%
Immunology and Microbiology 2 8%
Environmental Science 1 4%
Other 4 16%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2013.
All research outputs
#3,076,474
of 4,507,280 outputs
Outputs from Veterinary Research
#312
of 417 outputs
Outputs of similar age
#193,836
of 285,295 outputs
Outputs of similar age from Veterinary Research
#9
of 14 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.