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Mendeley readers
Attention Score in Context
| Title |
Down-Regulation of CTLA-4 by HIV-1 Nef Protein
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0054295 |
| Pubmed ID | |
| Authors |
Mohamed El-Far, Catherine Isabelle, Nicolas Chomont, Martin Bourbonnière, Simone Fonseca, Petronela Ancuta, Yoav Peretz, Younes Chouikh, Rabih Halwani, Olivier Schwartz, Joaquín Madrenas, Gordon J. Freeman, Jean-Pierre Routy, Elias K. Haddad, Rafick-Pierre Sékaly |
| Abstract |
HIV-1 Nef protein down-regulates several cell surface receptors through its interference with the cell sorting and trafficking machinery. Here we demonstrate for the first time the ability of Nef to down-regulate cell surface expression of the negative immune modulator CTLA-4. Down-regulation of CTLA-4 required the Nef motifs DD175, EE155 and LL165, all known to be involved in vesicle trafficking. Disruption of the lysosomal functions by pH-neutralizing agents prevented CTLA-4 down-regulation by Nef, demonstrating the implication of the endosomal/lysosomal compartments in this process. Confocal microscopy experiments visualized the co-localization between Nef and CTLA-4 in the early and recycling endosomes but not at the cell surface. Overall, our results provide a novel mechanism by which HIV-1 Nef interferes with the surface expression of the negative regulator of T cell activation CTLA-4. Down-regulation of CTLA-4 may contribute to the mechanisms by which HIV-1 sustains T cell activation, a critical step in viral replication and dissemination. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 22% |
| Student > Bachelor | 7 | 14% |
| Other | 5 | 10% |
| Student > Master | 5 | 10% |
| Researcher | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 33% |
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Immunology and Microbiology | 8 | 16% |
| Medicine and Dentistry | 3 | 6% |
| Chemical Engineering | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 9 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2018.
All research outputs
#8,322,148
of 24,896,578 outputs
Outputs from PLOS ONE
#108,698
of 215,687 outputs
Outputs of similar age
#89,654
of 292,133 outputs
Outputs of similar age from PLOS ONE
#2,096
of 5,023 outputs
Altmetric has tracked 24,896,578 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 215,687 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,133 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,023 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.