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Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis

Overview of attention for article published in Revista de Saúde Pública, December 2021
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Title
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis
Published in
Revista de Saúde Pública, December 2021
DOI 10.11606/s1518-8787.2021055003051
Pubmed ID
Authors

Michelle de Santana Xavier Ramos, Camilla da Cruz Martins, Elivan Silva Souza, Graciete Oliveira Vieira, Isaac Suzart Gomes-Filho, Ana Claudia Morais Godoy Figueiredo, Maurício Gomes Pereira, Simone Seixas da Cruz

Abstract

To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB: < 1,500g and < 37 weeks) to achieve full enteral nutrition. Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care.

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Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 22%
Unspecified 1 11%
Researcher 1 11%
Librarian 1 11%
Unknown 4 44%
Readers by discipline Count As %
Medicine and Dentistry 3 33%
Unspecified 1 11%
Arts and Humanities 1 11%
Unknown 4 44%