Title |
Active penetration of Trypanosoma cruzi into host cells: historical considerations and current concepts
|
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Published in |
Frontiers in immunology, January 2013
|
DOI | 10.3389/fimmu.2013.00002 |
Pubmed ID | |
Authors |
Wanderley de Souza, Tecia M. Ulisses de Carvalho |
Abstract |
In the present short review, we analyze past experiments that addressed the interactions of intracellular pathogenic protozoa (Trypanosoma cruzi, Toxoplasma gondii, and Plasmodium) with host cells and the initial use of the term active penetration to indicate that a protozoan "crossed the host cell membrane, penetrating into the cytoplasm." However, the subsequent use of transmission electron microscopy showed that, for all of the protozoans and cell types examined, endocytosis, classically defined as involving the formation of a membrane-bound vacuole, took place during the interaction process. As a consequence, the recently penetrated parasites are always within a vacuole, designated the parasitophorous vacuole (PV). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Colombia | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 64 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 21% |
Researcher | 13 | 19% |
Student > Master | 8 | 12% |
Professor | 6 | 9% |
Student > Bachelor | 5 | 7% |
Other | 15 | 22% |
Unknown | 6 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 29 | 43% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Medicine and Dentistry | 8 | 12% |
Immunology and Microbiology | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 5 | 7% |
Unknown | 8 | 12% |