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Basic science of osteoarthritis

Overview of attention for article published in Journal of Experimental Orthopaedics, September 2016
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Title
Basic science of osteoarthritis
Published in
Journal of Experimental Orthopaedics, September 2016
DOI 10.1186/s40634-016-0060-6
Pubmed ID
Authors

Magali Cucchiarini, Laura de Girolamo, Giuseppe Filardo, J. Miguel Oliveira, Patrick Orth, Dietrich Pape, Pascal Reboul

Abstract

Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 202 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 13%
Student > Bachelor 26 13%
Student > Ph. D. Student 22 11%
Researcher 19 9%
Other 11 5%
Other 25 12%
Unknown 73 36%
Readers by discipline Count As %
Medicine and Dentistry 42 21%
Biochemistry, Genetics and Molecular Biology 22 11%
Nursing and Health Professions 11 5%
Engineering 11 5%
Agricultural and Biological Sciences 10 5%
Other 28 14%
Unknown 78 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2016.
All research outputs
#18,471,305
of 22,888,307 outputs
Outputs from Journal of Experimental Orthopaedics
#251
of 328 outputs
Outputs of similar age
#244,523
of 322,146 outputs
Outputs of similar age from Journal of Experimental Orthopaedics
#4
of 6 outputs
Altmetric has tracked 22,888,307 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 328 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,146 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.