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Serum Uric Acid Levels and Cerebral Microbleeds in Patients with Acute Ischemic Stroke

Overview of attention for article published in PLOS ONE, January 2013
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Title
Serum Uric Acid Levels and Cerebral Microbleeds in Patients with Acute Ischemic Stroke
Published in
PLOS ONE, January 2013
DOI 10.1371/journal.pone.0055210
Pubmed ID
Authors

Wi-Sun Ryu, Chi Kyung Kim, Beom Joon Kim, Seung-Hoon Lee

Abstract

Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke. However, the association of uric acid with cerebral hemorrhage has seldom been tested. We aimed to elucidate the association between uric acid and cerebral microbleeds (CMBs), a hemorrhage-prone cerebral microangiopathy. Seven hundred twenty-four patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data, including uric acid level, and examined the presence of CMBs using T2*-weighted gradient-echo MRI. We used logistic regression analysis to examine an independent association between uric acid and CMBs. Two-hundred twenty-six patients had CMBs (31.2%). After adjusting for possible confounders, elevated uric acid was independently associated with the presence of CMBs (the highest quartile vs. lowest quartile, adjusted odd ratio [OR], 1.98; 95% confidence interval [CI], 1.16-3.39). This association retained in patients with deep or infratentorial CMBs (with or without lobar CMBs) but not among those with lobar CMBs. In addition, this association was robust among patients with hypertension (the highest quartile vs. lowest quartile, adjusted OR, 2.74; 95% CI, 1.43-5.24). In contrast, we did not find the association in patients without hypertension. We demonstrated that serum uric acid is independently associated with the presence of CMBs. In particular, the relation between uric acid and CMBs was robust in hypertensive patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 21%
Student > Postgraduate 3 13%
Student > Ph. D. Student 3 13%
Student > Doctoral Student 2 8%
Professor 2 8%
Other 3 13%
Unknown 6 25%
Readers by discipline Count As %
Medicine and Dentistry 13 54%
Neuroscience 2 8%
Agricultural and Biological Sciences 2 8%
Unknown 7 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2013.
All research outputs
#16,615,464
of 24,520,187 outputs
Outputs from PLOS ONE
#147,497
of 211,828 outputs
Outputs of similar age
#190,256
of 289,985 outputs
Outputs of similar age from PLOS ONE
#3,201
of 5,040 outputs
Altmetric has tracked 24,520,187 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 211,828 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,985 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,040 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.