Title |
Heterogeneous multimodal biomarkers analysis for Alzheimer’s disease via Bayesian network
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Published in |
EURASIP Journal on Bioinformatics & Systems Biology, August 2016
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DOI | 10.1186/s13637-016-0046-9 |
Pubmed ID | |
Authors |
Yan Jin, Yi Su, Xiao-Hua Zhou, Shuai Huang, The Alzheimer’s Disease Neuroimaging Initiative |
Abstract |
By 2050, it is estimated that the number of worldwide Alzheimer's disease (AD) patients will quadruple from the current number of 36 million, while no proven disease-modifying treatments are available. At present, the underlying disease mechanisms remain under investigation, and recent studies suggest that the disease involves multiple etiological pathways. To better understand the disease and develop treatment strategies, a number of ongoing studies including the Alzheimer's Disease Neuroimaging Initiative (ADNI) enroll many study participants and acquire a large number of biomarkers from various modalities including demographic, genotyping, fluid biomarkers, neuroimaging, neuropsychometric test, and clinical assessments. However, a systematic approach that can integrate all the collected data is lacking. The overarching goal of our study is to use machine learning techniques to understand the relationships among different biomarkers and to establish a system-level model that can better describe the interactions among biomarkers and provide superior diagnostic and prognostic information. In this pilot study, we use Bayesian network (BN) to analyze multimodal data from ADNI, including demographics, volumetric MRI, PET, genotypes, and neuropsychometric measurements and demonstrate our approach to have superior prediction accuracy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Student > Master | 6 | 13% |
Student > Postgraduate | 4 | 8% |
Researcher | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Other | 6 | 13% |
Unknown | 15 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 7 | 15% |
Computer Science | 5 | 10% |
Medicine and Dentistry | 4 | 8% |
Engineering | 3 | 6% |
Nursing and Health Professions | 3 | 6% |
Other | 9 | 19% |
Unknown | 17 | 35% |