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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
|
|---|---|
| Published in |
Journal of Natural Products, January 2022
|
| DOI | 10.1021/acs.jnatprod.1c00946 |
| Pubmed ID | |
| Authors |
Richard B. van Breemen, Ruth N. Muchiri, Timothy A. Bates, Jules B. Weinstein, Hans C. Leier, Scotland Farley, Fikadu G. Tafesse |
| Abstract |
As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2. |
Twitter Demographics
The data shown below were collected from the profiles of 26,933 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7514 | 28% |
| Canada | 574 | 2% |
| United Kingdom | 430 | 2% |
| Germany | 306 | 1% |
| France | 255 | <1% |
| Brazil | 222 | <1% |
| Australia | 221 | <1% |
| Sri Lanka | 213 | <1% |
| Comoros | 158 | <1% |
| Other | 2311 | 9% |
| Unknown | 14729 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25918 | 96% |
| Scientists | 428 | 2% |
| Science communicators (journalists, bloggers, editors) | 326 | 1% |
| Practitioners (doctors, other healthcare professionals) | 246 | <1% |
| Unknown | 15 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 237 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 237 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 34 | 14% |
| Student > Master | 29 | 12% |
| Student > Bachelor | 29 | 12% |
| Student > Ph. D. Student | 23 | 10% |
| Other | 17 | 7% |
| Other | 42 | 18% |
| Unknown | 63 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 13% |
| Chemistry | 29 | 12% |
| Medicine and Dentistry | 20 | 8% |
| Agricultural and Biological Sciences | 18 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 7% |
| Other | 52 | 22% |
| Unknown | 72 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13943. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2023.
All research outputs
#84
of 24,524,436 outputs
Outputs from Journal of Natural Products
#2
of 5,171 outputs
Outputs of similar age
#8
of 513,136 outputs
Outputs of similar age from Journal of Natural Products
#2
of 49 outputs
Altmetric has tracked 24,524,436 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,171 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 513,136 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.