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The Spider Effect: Morphological and Orienting Classification of Microglia in Response to Stimuli in Vivo

Overview of attention for article published in PLOS ONE, February 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

blogs
1 blog

Citations

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92 Dimensions

Readers on

mendeley
93 Mendeley
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Title
The Spider Effect: Morphological and Orienting Classification of Microglia in Response to Stimuli in Vivo
Published in
PLOS ONE, February 2012
DOI 10.1371/journal.pone.0030763
Pubmed ID
Authors

Rahul A. Jonas, Ti-Fei Yuan, Yu-Xiang Liang, Jost B. Jonas, David K. C. Tay, Rutledge G. Ellis-Behnke

Abstract

The different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: from stage 1A to 6A, the cell body size increased, the cell process number decreased, and the cell processes retracted and thickened, orienting toward the direction of the injury site; until stage 6A, when all processes disappeared. In contrast, in deactivation stages 6R to 1R, the microglia returned to the original site exhibiting a stepwise retransformation to the original morphology. Thin highly branched processes re-formed in stage 1R, similar to those in stage 1A. This reverse transformation mirrored the forward transformation except in stages 6R to 1R: cells showed multiple nuclei which were slowly absorbed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
Italy 1 1%
Unknown 90 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 25%
Student > Bachelor 15 16%
Researcher 12 13%
Student > Master 10 11%
Student > Doctoral Student 5 5%
Other 15 16%
Unknown 13 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 27%
Neuroscience 20 22%
Medicine and Dentistry 11 12%
Biochemistry, Genetics and Molecular Biology 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 11 12%
Unknown 17 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2013.
All research outputs
#3,896,054
of 22,694,633 outputs
Outputs from PLOS ONE
#55,838
of 193,729 outputs
Outputs of similar age
#25,451
of 156,344 outputs
Outputs of similar age from PLOS ONE
#712
of 3,530 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,729 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 3,530 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.