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A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Overview of attention for article published in Journal of Dermatological Treatment, August 2016
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Title
A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants
Published in
Journal of Dermatological Treatment, August 2016
DOI 10.1080/09546634.2016.1218417
Pubmed ID
Authors

Hans Stettler, Peter Kurka, Christine Wagner, Katarzyna Sznurkowska, Olga Czernicka, Arne Böhling, Stephan Bielfeldt, Klaus-Peter Wilhelm, Holger Lenz

Abstract

Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability in healthy infants. In Study 1 (N = 44), a single skin application of NTP-CE was performed followed by a 4-week twice-daily application. Skin hydration and stratum corneum (SC) water content change (using Raman spectroscopy) were measured. In the 4-week Study 2 (N = 65, aged 3-25 months), NTP-CE tolerability was assessed using a 5-point scoring system; skin hydration was determined in a subset (N = 21). In Study 1, mean AUC0 - 24 h for skin capacitance change from baseline was 302.03 i.u. with NTP-CE and -15.90 i.u. in control areas (p < .001). With NTP-CE (at 4 h), the water content within the upper SC part was reduced (-45.10 vs. -13.39 g/cm(2), p = .013) and the water gradient increased (0.51 vs. 0.11 g/cm(4), p = .036), indicating relocation of water into deeper layers. In Study 2, there was no statistically significant change from baseline in mean cutaneous tolerability scores. At days 7, 14, and 28, skin hydration had increased by 42%, 54%, and 49%, respectively (all p < .001). Single and prolonged NTP-CE usage is associated with sustained and deep skin moisturization. NTP-CE is well tolerated by healthy infants.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 12%
Researcher 6 12%
Student > Ph. D. Student 6 12%
Student > Master 5 10%
Student > Bachelor 4 8%
Other 3 6%
Unknown 21 41%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 16%
Agricultural and Biological Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Medicine and Dentistry 4 8%
Chemistry 4 8%
Other 8 16%
Unknown 18 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2017.
All research outputs
#15,879,351
of 24,195,945 outputs
Outputs from Journal of Dermatological Treatment
#654
of 1,123 outputs
Outputs of similar age
#216,016
of 349,690 outputs
Outputs of similar age from Journal of Dermatological Treatment
#6
of 15 outputs
Altmetric has tracked 24,195,945 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,123 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,690 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.