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TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

Overview of attention for article published in Science Translational Medicine, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

twitter
11 tweeters
patent
1 patent
wikipedia
4 Wikipedia pages
f1000
1 research highlight platform

Citations

dimensions_citation
570 Dimensions

Readers on

mendeley
367 Mendeley
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Title
TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation
Published in
Science Translational Medicine, January 2013
DOI 10.1126/scitranslmed.3005374
Pubmed ID
Authors

Brian S. Kim, Mark C. Siracusa, Steven A. Saenz, Mario Noti, Laurel A. Monticelli, Gregory F. Sonnenberg, Matthew R. Hepworth, Abby S. Van Voorhees, Michael R. Comeau, David Artis

Abstract

Innate lymphoid cells (ILCs) are a recently identified family of heterogeneous immune cells that can be divided into three groups based on their differential developmental requirements and expression of effector cytokines. Among these, group 2 ILCs produce the type 2 cytokines interleukin-5 (IL-5) and IL-13 and promote type 2 inflammation in the lung and intestine. However, whether group 2 ILCs reside in the skin and contribute to skin inflammation has not been characterized. We identify a population of skin-resident group 2 ILCs present in healthy human skin that are enriched in lesional human skin from atopic dermatitis (AD) patients. Group 2 ILCs were also found in normal murine skin and were critical for the development of inflammation in a murine model of AD-like disease. Remarkably, in contrast to group 2 ILC responses in the intestine and lung, which are critically regulated by IL-33 and IL-25, group 2 ILC responses in the skin and skin-draining lymph nodes were independent of these canonical cytokines but were critically dependent on thymic stromal lymphopoietin (TSLP). Collectively, these results demonstrate an essential role for IL-33- and IL-25-independent group 2 ILCs in promoting skin inflammation.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 367 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Germany 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Korea, Republic of 1 <1%
Unknown 358 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 78 21%
Researcher 69 19%
Student > Master 47 13%
Student > Bachelor 31 8%
Student > Doctoral Student 18 5%
Other 62 17%
Unknown 62 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 103 28%
Immunology and Microbiology 80 22%
Medicine and Dentistry 56 15%
Biochemistry, Genetics and Molecular Biology 31 8%
Neuroscience 4 1%
Other 22 6%
Unknown 71 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2021.
All research outputs
#2,141,199
of 22,330,240 outputs
Outputs from Science Translational Medicine
#2,658
of 5,032 outputs
Outputs of similar age
#24,167
of 283,174 outputs
Outputs of similar age from Science Translational Medicine
#46
of 108 outputs
Altmetric has tracked 22,330,240 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 80.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,174 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.