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RNA-DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World

Overview of attention for article published in Angewandte Chemie. International Edition, October 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#38 of 43,494)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
20 news outlets
blogs
3 blogs
twitter
23 tweeters
facebook
1 Facebook page
wikipedia
2 Wikipedia pages
googleplus
8 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
78 Mendeley
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Title
RNA-DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World
Published in
Angewandte Chemie. International Edition, October 2016
DOI 10.1002/anie.201607919
Pubmed ID
Authors

Jesse V. Gavette, Matthias Stoop, Nicholas V. Hud, Ramanarayanan Krishnamurthy

Abstract

The RNA world hypothesis posits that DNA and proteins were later inventions of early life, or the chemistry that gave rise to life. Most scenarios put forth for the emergence of DNA assume a clean separation of RNA and DNA polymer, and a smooth transition between RNA and DNA. However, based on the reality of "clutter" and lack of sophisticated separation/discrimination mechanisms in a protobiological (and/or prebiological) world, heterogeneous RNA-DNA backbone containing chimeric sequences could have been common-and have not been fully considered in models transitioning from an RNA world to an RNA-DNA world. Herein we show that there is a significant decrease in Watson-Crick duplex stability of the heterogeneous backbone chimeric duplexes that would impede base-pair mediated interactions (and functions). These results point to the difficulties for the transition from one homogeneous system (RNA) to another (RNA/DNA) in an RNA world with a heterogeneous mixture of ribo- and deoxyribonucleotides and sequences, while suggesting an alternative scenario of prebiological accumulation and co-evolution of homogeneous systems (RNA and DNA).

Twitter Demographics

The data shown below were collected from the profiles of 23 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Mexico 1 1%
Unknown 76 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 27%
Student > Bachelor 12 15%
Researcher 9 12%
Student > Master 8 10%
Professor > Associate Professor 5 6%
Other 14 18%
Unknown 9 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 33%
Chemistry 21 27%
Agricultural and Biological Sciences 9 12%
Physics and Astronomy 3 4%
Immunology and Microbiology 2 3%
Other 6 8%
Unknown 11 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 188. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2022.
All research outputs
#164,695
of 22,080,859 outputs
Outputs from Angewandte Chemie. International Edition
#38
of 43,494 outputs
Outputs of similar age
#3,741
of 292,612 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#3
of 897 outputs
Altmetric has tracked 22,080,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 43,494 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 897 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.