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Mendeley readers
Attention Score in Context
| Title |
11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE−/− Mice
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0053192 |
| Pubmed ID | |
| Authors |
Ricardo A. García, Debra J. Search, John A. Lupisella, Jacek Ostrowski, Bo Guan, Jian Chen, Wen-Pin Yang, Amy Truong, Aiqing He, Rongan Zhang, Mujing Yan, Samuel E. Hellings, Peter S. Gargalovic, Carol S. Ryan, Linda M. Watson, Robert A. Langish, Petia A. Shipkova, Nancy L. Carson, Joseph R. Taylor, Richard Yang, George C. Psaltis, Thomas W. Harrity, Jeffrey A. Robl, David A. Gordon |
| Abstract |
Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) increases active glucocorticoid levels within tissues by catalyzing the conversion of cortisone to cortisol. Pharmacological inhibition of 11βHSD1 has been shown to reduce atherosclerosis in murine models. However, the cellular and molecular details for this effect have not been elucidated. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 2% |
| Spain | 1 | 2% |
| Netherlands | 1 | 2% |
| Belgium | 1 | 2% |
| Unknown | 43 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 19% |
| Researcher | 6 | 13% |
| Student > Bachelor | 6 | 13% |
| Professor > Associate Professor | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 8 | 17% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 26% |
| Medicine and Dentistry | 11 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Psychology | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 12 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2013.
All research outputs
#20,180,477
of 22,694,633 outputs
Outputs from PLOS ONE
#172,890
of 193,729 outputs
Outputs of similar age
#249,468
of 282,530 outputs
Outputs of similar age from PLOS ONE
#4,161
of 5,001 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,729 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,530 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,001 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.