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MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

Overview of attention for article published in PLOS ONE, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Citations

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175 Dimensions

Readers on

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143 Mendeley
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Title
MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments
Published in
PLOS ONE, January 2013
DOI 10.1371/journal.pone.0055013
Pubmed ID
Authors

Craig W. Hendrix, Beatrice A. Chen, Vijayanand Guddera, Craig Hoesley, Jessica Justman, Clemensia Nakabiito, Robert Salata, Lydia Soto-Torres, Karen Patterson, Alexandra M. Minnis, Sharavi Gandham, Kailazarid Gomez, Barbra A. Richardson, Namandje N. Bumpus

Abstract

Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection have demonstrated variable efficacy in men and women prompting assessment of variation in drug concentration as an explanation. Knowledge of tenofovir concentration and its active form, tenofovir diphosphate, at the putative vaginal and rectal site of action and its relationship to concentrations at multiple other anatomic locations may provide key information for both interpreting PrEP study outcomes and planning future PrEP drug development.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
United States 1 <1%
Czechia 1 <1%
Brazil 1 <1%
Unknown 139 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 19%
Researcher 25 17%
Student > Ph. D. Student 18 13%
Student > Bachelor 17 12%
Student > Doctoral Student 9 6%
Other 25 17%
Unknown 22 15%
Readers by discipline Count As %
Medicine and Dentistry 48 34%
Pharmacology, Toxicology and Pharmaceutical Science 15 10%
Agricultural and Biological Sciences 11 8%
Nursing and Health Professions 9 6%
Biochemistry, Genetics and Molecular Biology 6 4%
Other 24 17%
Unknown 30 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2014.
All research outputs
#1,136,881
of 22,694,633 outputs
Outputs from PLOS ONE
#15,223
of 193,729 outputs
Outputs of similar age
#11,115
of 282,145 outputs
Outputs of similar age from PLOS ONE
#360
of 5,012 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,729 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,145 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 5,012 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.