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Age-Related Hearing Loss in Rhesus Monkeys Is Correlated with Cochlear Histopathologies

Overview of attention for article published in PLOS ONE, February 2013
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Title
Age-Related Hearing Loss in Rhesus Monkeys Is Correlated with Cochlear Histopathologies
Published in
PLOS ONE, February 2013
DOI 10.1371/journal.pone.0055092
Pubmed ID
Authors

James R. Engle, Steve Tinling, Gregg H. Recanzone

Abstract

Audiometric hearing deficits are a common symptom of age-related hearing loss (ARHL), as are specific histopathological changes in the cochlea; however, very little data have been collected in non-human primates. To examine this relationship further, we collected auditory brainstem responses (ABRs) from rhesus monkeys spanning in age from 10 to 35 years old, and examined four different morphological features of their cochleae. We found significant correlations between ABR thresholds and the loss of outer hair cells and spiral ganglion cells, but not with the loss of inner hair cells or a reduced thickness of the stria vascularis. The strongest correlation with ABR thresholds was the number of different pathologies present. These findings show that while aged rhesus monkeys experience audiometric hearing deficits similar to that seen in humans, they are not correlated with a single peripheral deficit, but instead with a number of different underlying cochlear histopathologies, indicating that similar histopathologies may exist in geriatric humans as well.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 20%
Student > Ph. D. Student 9 15%
Student > Bachelor 6 10%
Professor > Associate Professor 5 8%
Student > Master 5 8%
Other 15 25%
Unknown 8 13%
Readers by discipline Count As %
Medicine and Dentistry 14 23%
Neuroscience 14 23%
Engineering 7 12%
Agricultural and Biological Sciences 6 10%
Psychology 5 8%
Other 6 10%
Unknown 8 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2013.
All research outputs
#20,180,477
of 22,694,633 outputs
Outputs from PLOS ONE
#172,890
of 193,729 outputs
Outputs of similar age
#249,794
of 283,057 outputs
Outputs of similar age from PLOS ONE
#4,152
of 5,006 outputs
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