Title |
An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control
|
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Published in |
BMC Genomics, November 2012
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DOI | 10.1186/1471-2164-13-664 |
Pubmed ID | |
Authors |
Hannah C Cheung, F Anthony San Lucas, Stephanie Hicks, Kyle Chang, Alison A Bertuch, Albert Ribes-Zamora |
Abstract |
The cellular response to DNA damage is immediate and highly coordinated in order to maintain genome integrity and proper cell division. During the DNA damage response (DDR), the sensor kinases Tel1 and Mec1 in Saccharomyces cerevisiae and ATM and ATR in human, phosphorylate multiple mediators which activate effector proteins to initiate cell cycle checkpoints and DNA repair. A subset of kinase substrates are recognized by the S/T-Q cluster domain (SCD), which contains motifs of serine (S) or threonine (T) followed by a glutamine (Q). However, the full repertoire of proteins and pathways controlled by Tel1 and Mec1 is unknown. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 5% |
United States | 1 | 2% |
Unknown | 41 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 32% |
Researcher | 10 | 23% |
Student > Master | 7 | 16% |
Student > Bachelor | 5 | 11% |
Professor > Associate Professor | 4 | 9% |
Other | 4 | 9% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 27 | 61% |
Biochemistry, Genetics and Molecular Biology | 15 | 34% |
Mathematics | 1 | 2% |
Social Sciences | 1 | 2% |