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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Comparative Population Plasma and Tissue Pharmacokinetics of Micafungin in Critically Ill Patients with Severe Burn Injuries and Patients with Complicated Intra-Abdominal Infection
|
|---|---|
| Published in |
Antimicrobial Agents and Chemotherapy, September 2016
|
| DOI | 10.1128/aac.00727-16 |
| Pubmed ID | |
| Authors |
A. García-de-Lorenzo, S. Luque, S. Grau, A. Agrifoglio, L. Cachafeiro, E. Herrero, M. J. Asensio, S. M. Sánchez, J. A. Roberts |
| Abstract |
Severely burned patients have altered drug pharmacokinetics but it is unclear how different it is from other critically ill patient groups. The aim was to compare the population pharmacokinetics of micafungin in plasma and burn eschar in severely burned patients with micafungin in plasma and peritoneal fluid of postsurgical critically-ill patients with intra-abdominal infection. Fifteen burned patients were compared with 10 patients with intra-abdominal infection, all treated with 100-150mg/day of micafungin. Micafungin concentrations were determined in serial blood, peritoneal fluid and burn tissue samples and were subjected to a population pharmacokinetic analysis. The probability of target attainment was calculated using AUC0-24/MIC cutoffs: 285 (C. parapsilosis) and 3000 (non-parapsilosis Candida spp.), by Montecarlo simulations. Twenty-five patients included (18 male, median (range) 50 (38-67) years, total body surface area burned 50% (35-65) in burns). A three compartment model described the data and only the rate constant for drug distribution from the tissue fluid to central compartment was statistically different between burns and intra-abdominal infection patients (0.47 (0.47) vs 0.15 (0.06) h(-1); p<0.05), respectively. Most patients would achieve plasma PK/PD targets for 90% of non-parapsilosis Candida spp. and C. parapsilosis with MICs of 0.008 and 0.064 for 100mg daily and 150mg daily doses, respectively. The PK of micafungin is not significantly different between burns in intra-abdominal infection patients. After the first dose, micafungin 100 mg/day achieves PK/PD targets in plasma for MICs values ≤ 0.008 mg/L and ≤ 0.064 mg/L for non-parapsilosis Candida spp. and Candida parapsilosis species, respectively. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 19% |
| Student > Ph. D. Student | 6 | 16% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Lecturer | 3 | 8% |
| Other | 9 | 24% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 30% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 27% |
| Immunology and Microbiology | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 10 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2016.
All research outputs
#3,415,880
of 25,377,790 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#2,393
of 15,580 outputs
Outputs of similar age
#54,992
of 329,365 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#134
of 261 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,580 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,365 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 261 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.