Title |
Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?
|
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Published in |
Drug Design, Development and Therapy, September 2016
|
DOI | 10.2147/dddt.s112389 |
Pubmed ID | |
Authors |
Jan M Keppel Hesselink, Flavia Chiosi, Ciro Costagliola |
Abstract |
Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives - RX-10045. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 19% |
Student > Ph. D. Student | 8 | 15% |
Researcher | 5 | 9% |
Other | 4 | 8% |
Student > Master | 4 | 8% |
Other | 8 | 15% |
Unknown | 14 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Chemistry | 5 | 9% |
Agricultural and Biological Sciences | 4 | 8% |
Immunology and Microbiology | 4 | 8% |
Other | 9 | 17% |
Unknown | 15 | 28% |