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Host cytoskeleton in respiratory syncytial virus assembly and budding

Overview of attention for article published in Virology Journal, September 2016
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1 tweeter

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68 Mendeley
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Title
Host cytoskeleton in respiratory syncytial virus assembly and budding
Published in
Virology Journal, September 2016
DOI 10.1186/s12985-016-0618-z
Pubmed ID
Authors

Shadi Shahriari, James Gordon, Reena Ghildyal

Abstract

Respiratory syncytial virus (RSV) is one of the major pathogens responsible for lower respiratory tract infections (LRTI) in young children, the elderly, and the immunosuppressed. Currently, there are no antiviral drugs or vaccines available that effectively target RSV infections, proving a significant challenge in regards to prevention and treatment. An in-depth understanding of the host-virus interactions that underlie assembly and budding would inform new targets for antiviral development.Current research suggests that the polymerised form of actin, the filamentous or F-actin, plays a role in RSV assembly and budding. Treatment with cytochalasin D, which disrupts F-actin, has been shown to inhibit virus release. In addition, the actin cytoskeleton has been shown to interact with the RSV matrix (M) protein, which plays a central role in RSV assembly. For this reason, the interaction between these two components is hypothesised to facilitate the movement of viral components in the cytoplasm and to the budding site. Despite increases in our knowledge of RSV assembly and budding, M-actin interactions are not well understood. In this review, we discuss the current literature on the role of actin cytoskeleton during assembly and budding of RSV with the aim to integrate disparate studies to build a hypothetical model of the various molecular interactions between actin and RSV M protein that facilitate RSV assembly and budding.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 25%
Student > Ph. D. Student 16 24%
Student > Bachelor 10 15%
Researcher 6 9%
Professor > Associate Professor 3 4%
Other 6 9%
Unknown 10 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 28%
Biochemistry, Genetics and Molecular Biology 14 21%
Immunology and Microbiology 8 12%
Medicine and Dentistry 4 6%
Chemistry 3 4%
Other 5 7%
Unknown 15 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2016.
All research outputs
#6,404,245
of 8,440,126 outputs
Outputs from Virology Journal
#1,335
of 1,692 outputs
Outputs of similar age
#176,744
of 252,904 outputs
Outputs of similar age from Virology Journal
#34
of 41 outputs
Altmetric has tracked 8,440,126 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,692 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.